For daily and periodic pc cleaning (Windows) I use the following tools:
- Cleaning: CCleaner + Wise Registery Cleaner
- Startup improvements: Autoruns by Sysinternals / Startup Delayer 2
- Program removal: Wise Program Uninstaller
- Defragmentation: Defraggler (by the makers of CCleaner)
- Malware removal: AdwCleaner / Spybot Seach & Destroy / Malwarebytes Anti-Malware